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Year : 2011  |  Volume : 6  |  Issue : 4  |  Page : 270-283

Myopia and Inflammation

1 Inflammatory and Retinal Eye Diseases, Center for Ophthalmic Specialized Care; University of Lausanne, Lausanne, Switzerland
2 Inflammatory and Retinal Eye Diseases, Center for Ophthalmic Specialized Care, Lausanne, Switzerland; Eye Clinic, Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
3 The Eye Clinic, Polytechnic University of Marche, Ancona, Italy

Correspondence Address:
Carl P Herbort
Inflammatory and Retinal Eye Diseases, Center for Ophthalmic Specialized Care (COS), Clinique Montchoisi, Rue de la Grotte 6, 1003 Lausanne, Switzerland

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Source of Support: None, Conflict of Interest: None

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The correlation between myopia and intraocular inflammation has rarely been explored. The aim of this article is to review myopic changes induced by inflammatory diseases and inflammatory diseases related to myopia, followed by a discussion on inflammatory choroidal neovascularization. Clinical cases are used to illustrate these conditions. The review does not include inflammatory conditions caused by surgical interventions employed for treatment of myopia. Uveitic conditions that can induce a myopic shift include sclero-choroidal inflammation, lens induced myopia due to steroid cataracts, juvenile idiopathic arthritis (JIA) induced myopia, and transient drug induced myopia due to sulfonamides and acetazolamide used for treatment of ocular toxoplasmosis and inflammatory cystoid macular edema, respectively. Most inflammatory conditions related to myopia are conditions involving the choriocapillaris. These include multifocal choroiditis and/or punctate inner choroiditis, multiple evanescent white dot syndrome and acute idiopathic blind spot enlargement. It can be hypothesized that fragility of the choriocapillaris due to particular anatomic changes due to myopia, together with unknown immunogenetic factors predispose myopic eyes to primary inflammatory choriocapillaropathies.

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