|Year : 2014 | Volume
| Issue : 4 | Page : 517-519
Orbital metastasis: A rare manifestation of scapular bone osteosarcoma
Mohammad Taher Rajabi MD , Hajar Jafari MD , Seyedeh Simindokht Hosseini MD , Seyed Ziaeddin Tabatabaie MD , Mohammad Bagher Rajabi MD , Fahimeh Asadi Amoli MD
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
|Date of Submission||21-Aug-2013|
|Date of Acceptance||16-Nov-2013|
|Date of Web Publication||5-Feb-2015|
Mohammad Taher Rajabi
Eye Research Center, Farabi Eye Hospital, Qazvin Square, Tehran
Source of Support: None, Conflict of Interest: None
Purpose: To report a case of orbital metastasis from scapular bone osteosarcoma.
Case Report: A 55-year-old man who was a known case of scapular bone osteosarcoma, was referred to our clinic with ocular symptoms including acute painful decreased vision, proptosis, conjunctival injection, and chemosis. He had undergone surgical excision of the original tumor and received systemic chemotherapy 4 months before. Imaging studies and incisional biopsy were performed for the orbital lesion, the histopathological examination confirmed the diagnosis of metastatic osteosarcoma. The patient was referred to the oncologist for palliative chemotherapy and further intervention; however, he deceased 2 months later due to sepsis in the context of immunosuppression.
Conclusion: Metastatic involvement of the orbit due to osteosarcoma is a rare condition manifesting with orbital mass, pain, diplopia and ocular motility disturbance. Although there is no effective treatment, the combination of modalities such as chemotherapy, radiotherapy, and surgery may delay progression of the disease.
Keywords: Metastasis; Orbit; Osteosarcoma
|How to cite this article:|
Rajabi MT, Jafari H, Hosseini SS, Tabatabaie SZ, Rajabi MB, Amoli FA. Orbital metastasis: A rare manifestation of scapular bone osteosarcoma. J Ophthalmic Vis Res 2014;9:517-9
|How to cite this URL:|
Rajabi MT, Jafari H, Hosseini SS, Tabatabaie SZ, Rajabi MB, Amoli FA. Orbital metastasis: A rare manifestation of scapular bone osteosarcoma. J Ophthalmic Vis Res [serial online] 2014 [cited 2020 Jul 2];9:517-9. Available from: http://www.jovr.org/text.asp?2014/9/4/517/150834
| Introduction|| |
Metastatic orbital lesion due to osteosarcoma is a rare condition and manifestations include orbital mass, pain, diplopia, chemosis and ocular motility disturbance depending on the location of the mass and its effect on adjacent structures. There is no effective treatment, but the combination of treatment modalities including chemotherapy, radiotherapy and surgery for tumor debulking may delay disease progression. Herein, we report a case of orbital metastasis from scapular bone osteosarcoma.
| Case report|| |
A 55-year-old man was referred to the Oculoplastics Clinic at Farabi Eye Hospital, Tehran, Iran with acute onset painful decrease of vision and protrusion of his left eye. He was a known case of left scapular bone osteosarcoma and had undergone surgical excision of the original tumor and chemotherapy, approximately 4 months before. Visual acuity was counting fingers and 20/20 in the left and right eyes, respectively. Ophthalmic examination revealed proptosis, severe lid swelling, chemosis and conjunctival injection in his left eye [Figure 1]. There was profound gaze limitation in all directions in the left eye. Dilated fundus examination was normal in both eyes.
|Figure 1. Appearance of the patient at presentation revealed proptosis, severe lid swelling and chemosis of the left eye.|
Click here to view
In the next step, orbital CT-scan revealed a large heterogeneous mass lesion in the left intraconal orbital space with tiny foci of hyperintensity [Figure 2]. For further investigation, MRI was done in which an intraconal lesion, hypointense in some planes and hyperintense in others, was noted on T1 images [[Figure 3]a]. The intensity of the lesion was heterogeneous to hyperintense on T2 images [[Figure 3]b and c] which also displayed ring enhancement on gadolinium enhanced T1 images [[Figure 3]d].
|Figure 2. Orbital CT scan shows a heterogeneous intraconal mass lesion with small foci of hyperdensity. Axial view (a) Coronal view (b).|
Click here to view
|Figure 3. Orbital MRI showed an intraconal mass that was heterogeneous to hyperintense on T1 images (a) and heterogeneous to hyperintense on T2 images (b and c) with gadolinium enhancement at the rim of the lesion on T1 images (d). In some sections, the mass seems to be hyperintense on T1 images (a) and in some others, hypointense (d). The same finding can be seen on T2 images (b and c).|
Click here to view
The patient underwent incisional biopsy through a lateral orbitotomy. Histopathological examination of the tumor revealed malignant spindle cells with osteoid formation and mineralization which was compatible with metastatic osteosarcoma [Figure 4].
|Figure 4. Histopathological studies revealed malignant spindle cells with osteoid formation and mineralization compatible with metastatic osteosarcoma.|
Click here to view
The orbital metastasis being confirmed, the patient underwent systemic evaluation for any other site of metastasis; however, there was no other organ involvement. The patient was referred to his oncologist for palliative chemotherapy. Unfortunately, after 2 months of chemotherapy, he deceased in the clinical setting of sepsis probably due to systemic immunosuppression.
| Discussion|| |
Osteosarcoma is the most common malignant bone tumor and may involve the long bones of young adults primarily.  It can be seen in association with hereditary retinoblastoma, previous exposure to ionizing radiation or Paget disease.  The most common site of involvement is the medulla of the metaphysis in long bones, particularly the distal femur, proximal tibia and proximal humerus.  It has been classified conventionally into osteoblastic (50%), chondroblastic (25%) and fibroblastic (<25%) variants; a small percentage of them are categorized into telangiectatic, small cell multifocal, parosteal, periosteal, and extra-osseous variants. 
These tumors are very invasive and metastasize in approximately 20% of patients.  Factors affecting prognosis include tumor histopathology, size, raised pre- and post-operative serum alkaline phosphatase levels, involvement of lymph nodes and treatment modality. However, age, gender, history of trauma or bone fracture and the site of primary osteosarcoma do not influence prognosis.  The most common sites for metastases for tumors originating from long bones is the lung and the second one are bones. 
By advances in systemic chemotherapy regimens, the long-term survival of patients without metastasis has now improved to 70%; however, in patients with metastasis or disease recurrence, survival is <20%. ,
Metastatic involvement of the orbit is a rare condition; orbital metastasis can originate from any primary tumor in the body.  The most common solid tumors in adults with orbital metastasis are breast and lung tumors, followed by cancers of the genitourinary tract and gastrointestinal system.  Some studies showed that leukemia and neuroblastoma are the most frequent causes of orbital metastasis.  Ewing's sarcoma and Wilms tumor are less frequently the source of orbital metastasis. 
The most common symptoms of metastatic orbital osteosarcoma are pain, diplopia and ocular dysmotility. Less common clinical manifestations include chemosis, epiphora and loss of vision.  Misra et al  reported the first case of osteosarcoma metastasizing to the orbit. The patient was an 8-year-old boy with osteosarcoma in his right tibia with involvement of the right eye 1 month after the diagnosis. Attili et al  reported another case with right tibial osteosarcoma, painful protrusion of the right eyeball and metastatic orbital osteosarcoma.
It is interesting that in all previously reported cases of metastatic orbital osteosarcoma, the primary and metastatic sites were both on the right side, ,, but in the present case, both of them originated from the left side. In previous reports, the primary site of osteosarcoma was the right tibia and in our case, it was the left scapula which may explain left orbit preference. As the current case is only the fifth subject with metastatic orbital osteosarcoma, this finding can be purely coincidental. However, it is notable that in all cases with metastatic orbital osteosarcoma, the lung was not involved by metastasis. It is believed that spread of tumor cells to the orbit may occur through Botson's paravertebral venous plexus which has already been hypothesized in other studies. 
Orbital MRI features were also challenging in our case. Most metastatic osteosarcomas show hyperintense signal on T1 scans, whereas signal intensity was heterogeneous to high in our case. We assume that various amounts of necrosis, hemorrhage and mineralization in osteoid tissue may have resulted in this particular presentation on T1-weighted images. Typical ring enhancement was seen on gadolinium enhanced images and a heterogeneous mass was revealed on T2 sections.
There are no specific guidelines for management of orbital metastases. Combination therapy using different treatment modalities including radiotherapy, chemotherapy and surgery may be effective for palliative measures, maintenance of vision and regression of metastatic tumor.
| References|| |
Philip T, Blay JY, Brunat-Mentigny M, Carrie C, Chauvot P, Farsi F, et al.
Osteosarcoma. Br J Cancer
2001;84 Suppl 2:78-80.
Mohadjer Y, Wilson MW, Fuller CE, Haik BG. Primary pelvic telangiectatic osteosarcoma metastatic to both orbits. Ophthal Plast Reconstr Surg
Giuliano AE, Feig S, Eilber FR. Changing metastatic patterns of osteosarcoma. Cancer
Van Glabbeke M, van Oosterom AT, Oosterhuis JW, Mouridsen H, Crowther D, Somers R, et al.
Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: An analysis of 2,185 patients treated with anthracycline-containing first-line regimens - A European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol
McKenna RJ, Schwinn CP, Soong KY, Higinbotham NL. Sarcomate of the osteogenic series (osteosarcoma, fibrosarcoma, chondrosarcoma, parosteal osteogenic sarcoma, and sarcomata arising in abnormal bone): An analysis of 552 cases. J Bone Joint Surg Am
Malawer MM, Helman LJ, O'Sullivan B. Sarcomas of bone. In: DeVita VT Jr, Hellman S, Rosenberg SA, editors. Cancer Principles and Practice of Oncology. 7 th
ed. New York: Lippincott Williams and Wilkins; 2006. p. 1638-1687.
Clark MA, Fisher C, Judson I, Thomas JM. Soft-tissue sarcomas in adults. N Engl J Med
Peyster RG, Shapiro MD, Haik BG. Orbital metastasis: Role of magnetic resonance imaging and computed tomography. Radiol Clin North Am
Duane TD, Jaeger EA, Jakobiec FA, Rootman J, Jones IS. Secondary and metastatic tumors of the orbit. In: Duane TD, Jaeger EA, editors. Clinical Ophthalmology. Philadelphia: JB Lippincott; 1982. p. 1-67.
Jain IS, Dinesh K, Mohan K. Ocular and orbital metastasis from systemic malignancies. Indian J Ophthalmol
Misra A, Misra S, Chaturvedi A, Srivastava PK. Osteosarcoma with metastasis to orbit. Br J Ophthalmol
Attili SV, Jain A, Saini KV, Batra U, Govind Babu K, Sajeevan KV, et al.
Orbital metastasis: A rare presentation of osteosarcoma. Int Ophthalmol
Lin PY, Chen WM, Hsieh YL, Chen WY, Chen TH. Orbital metastatic osteosarcoma. J Chin Med Assoc
[Figure 1], [Figure 2], [Figure 3], [Figure 4]