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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 155-159

Tumor necrosis factor gene polymorphisms in advanced non-exudative age-related macular degeneration


1 Department of Ophthalmology, Gonabad University of Medical Sciences, Gonabad; Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2 Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
3 Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Retina Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Biostatistics and Epidemiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
6 Department of Ophthalmology, Gonabad University of Medical Sciences, Gonabad, Iran

Correspondence Address:
Mohammad Hossein Jabbarpoor Bonyadi
Department of Ophthalmology, 22nd of Bahman Hospital, Naser Khosro Street, Gonabad
Iran
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Source of Support: Nil., Conflict of Interest: None


DOI: 10.4103/2008-322X.163781

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Purpose: To investigate tumor necrosis factor (TNF)-α gene polymorphisms in advanced dry-type age-related macular degeneration (AMD) in a population from Northeastern Iran. Methods: In this case-control study, 50 patients with geographic macular atrophy and 73 gender-matched controls were enrolled. Genomic deoxyribonucleic acid (DNA) was extracted from the peripheral blood. Polymerase chain reaction was performed to analyze 2 candidate single nucleotide polymorphisms in the TNF-α gene, namely −1031 thymine (T)/cytosine (C) and −308 guanine (G)/adenine (A). Results: The distribution of the - 1031 T/C genotype was TT, 62%; TC, 36%; CC, 2% in the patients and TT, 60%; TC, 36%; CC, 4% in the controls (P = 0.94). Genotype analysis of TNF-α −308 also revealed no significant difference in distribution between patients (G, 78%; GA, 22%; AA, 0%) and controls (GG, 74%; GA, 23%; AA, 3%) (P = 0.51). None of the haplotypes nor alleles of studied TNF-α polymorphisms were significantly associated with advanced dry-type AMD. Conclusion: The findings of this study show that polymorphisms in the TNF-α gene, do not play an important role in dry-type AMD in the studied population.


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