• Users Online: 104
  • Home
  • Print this page
  • Email this page
Home Current issue Ahead of print Search About us Abstracting and Indexing Editorial board Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 329-339

Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina


1 Department of Ophthalmology and Cell Biology, SUNY Downstate Medical Center, Brooklyn NY; SUNY Eye Institute, NY, USA
2 Department of Ophthalmology and Cell Biology, SUNY Downstate Medical Center; SUNY Eye Institute; Department of Ophthalmology and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA

Correspondence Address:
William J Brunken
Department of Ophthalmology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2008-322X.170354

Rights and Permissions

While genetic networks and other intrinsic mechanisms regulate much of retinal development, interactions with the extracellular environment shape these networks and modify their output. The present review has focused on the role of one family of extracellular matrix molecules and their signaling pathways in retinal development. In addition to their effects on the developing retina, laminins play a role in maintaining Müller cell polarity and compartmentalization, thereby contributing to retinal homeostasis. This article which is intended for the clinical audience, reviews the fundamentals of retinal development, extracellular matrix organization and the role of laminins in retinal development. The role of laminin in cortical development is also briefly discussed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2043    
    Printed14    
    Emailed0    
    PDF Downloaded313    
    Comments [Add]    
    Cited by others 5    

Recommend this journal