ORC ID , Elon H C van Dijk2, Sunila Dumpala3, Bindu Rajesh4, Ayesha Jabeen3, Asiya Jabeen3, Momin Ansari3, Pooja Mehta5, Shilpi Shah6, Chintan Sarvaiya6, Catherine Meyerle5, Lihteh Wu7, Alay Banker6, Camiel J Boon2, Jay Chhablani3 ORC ID ">
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Year : 2019  |  Volume : 14  |  Issue : 2  |  Page : 164-170

Evaluation of choroidal layer thickness in central serous chorioretinopathy

1 Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
2 Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
3 Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, Telangana, India
4 Department of Ophthalmology, Giridhar Eye Institute, Kochi, Kerala, India
5 Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
6 Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Ahmedabad, Gujarat, India
7 Asociados de Mácula Vitreo y Retina de Costa Rica, Apdo 144-1225 Plaza Mayor, San Jose, Costa Rica

Correspondence Address:
Jay Chhablani
Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, Kallam Anji Reddy campus, L V Prasad Eye Institute, Hyderabad 500034
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jovr.jovr_152_17

Clinical trial registration IRCT2014030116782N1

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Purpose: To evaluate medium and large choroidal vessel layer thickness (MCVT and LCVT, respectively) in eyes with acute and chronic central serous chorioretinopathy (CSC) in comparison with age-matched controls. Methods: The study included 96 eyes of 96 patients with CSC, including 53 eyes with acute CSC, 43 eyes with chronic CSC, and 30 eyes of 30 age-matched normal subjects. Manual measurements of subfoveal choroidal thickness (SFCT), MCVT, and LCVT at subfoveal and 750 μm nasal and temporal to the fovea locations were made on enhanced depth imaging optical coherence tomography (EDI-OCT) of the macula in all subjects using ImageJ software (National Institutes of Health, Bethesda, MD, USA). Results: SFCT in acute CSC was significantly larger than that in healthy eyes (P = 0.0001). SFCT in acute CSC did not differ significantly from that in chronic CSC eyes. Subfoveal LCVT and MCVT in acute CSC eyes were greater than those in healthy eyes (P = 0.02 and P = 0.03, respectively). Mean SFCT and MCVT in chronic CSC eyes were significantly larger than those in control eyes (P = 0.01 and P = 0.04, respectively). No significant difference in LCVT was observed between chronic and control eyes. Conclusion: Choroidal vasculature is altered in both acute and chronic CSC. SFCT, MCVT, and LCVT are higher in eyes with acute CSC. The thickening of medium choroidal vessels is still detectable in chronic CSC compared to control eyes.

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