Figure 4. Laminin assembly in basement membranes. Laminins self-polymerize in the extracellular space through their LN domains and create a "nascent" scaffold. A self-assembled collagen polymer joins this scaffold, which is further linked by nidogen (Nd), perlecan (Perl) and agrin (not shown), resulting in increased stability and complexity of the basement membrane (grey surface). Laminins in the basement membrane (e.g., here, Lm-111) interact via their G domain with cell receptors including integrins (here, integrin β1 subunit shown) and dystroglycan (DG) for anchorage. Col IV, Type IV Collagen; Nd, nidogen; Perl, perlecan; Modified from Li et al, noncommercial reuse permitted by Rockefeller University Press.