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  Indian J Med Microbiol
 

Figure 6. Integrins influence multiple functions by anchoring cells to the extracellular matrix (ECM). Integrins and dystroglycan in the extracellular space act as a bridge between the laminin-containing ECM and the cytoskeleton of the cell in the cytosol including dystrophin, resulting in changes in cell polarity, shape and migration. Integrins, after binding to the ECM, also act as signaling platforms by recruiting adaptors and signaling enzymes that control differentiation, shape and migration.

Figure 6. Integrins influence multiple functions by anchoring cells to the extracellular matrix (ECM). Integrins and dystroglycan in the extracellular space act as a bridge between the laminin-containing ECM and the cytoskeleton of the cell in the cytosol including dystrophin, resulting in changes in cell polarity, shape and migration. Integrins, after binding to the ECM, also act as signaling platforms by recruiting adaptors and signaling enzymes that control differentiation, shape and migration.