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  Indian J Med Microbiol
 

Figure 1. Norrin/-catenin signalling pathway. The binding of Norrin ligand to the receptor complex which consists of Fzd4, Lrp5 and Tspan12 protein components. The binding results in the activation of downstream -catenin signaling pathway which initiates the vascularisation process in the retina.[8],[9]

Figure 1. Norrin/-catenin signalling pathway. The binding of Norrin ligand to the receptor complex which consists of Fzd4, Lrp5 and Tspan12 protein components. The binding results in the activation of downstream -catenin signaling pathway which initiates the vascularisation process in the retina.<sup>[8],[9]</sup>